The Biohacker’s Guide to a High-Performing Liver
Siggi Clavien — Founder & CEO @ The Liver Clinic, De-Liver-Ance
Siggi Clavien is an innovative entrepreneur transforming liver health care globally. As Founder and CEO of The Liver Clinic and de-liver-ance, he leads a team focused on preventing and treating liver diseases. Siggi’s diverse expertise blends viticulture from UC Davis and Plant Medicine from Cornell with biotechnology, traditional herbal knowledge, and 28 years of Phytomedicine formulation and development. Inspired by his mother’s nursing heritage and influenced by his father’s winemaking background, Siggi is personally driven by the loss of loved ones to liver disease. Balancing life between the U.S. and London, he’s committed to raising awareness and supporting affected communities.
The liver, the largest internal organ, performs 500 vital functions including nutrient synthesis, detoxification, and immune regulation, yet liver disease is a rapidly escalating silent killer with fatty liver disease now affecting over 1.5 billion worldwide, linked to cardiovascular disease, type 2 diabetes, and metabolic syndrome. Genetic predispositions intensify risk alongside processed foods, toxins, inactivity, and polypharmacy. Liver disease often remains undetected by blood tests. Noninvasive Fibroscan technology accurately measures liver fat and fibrosis. Fatty liver and cirrhosis are reversible through lifestyle changes, phytomedicines, and emerging stem cell therapies.
"The liver is the most important organ for longevity, the immune system, and detoxification. It controls and synthesizes all nutrients, regenerates constantly, and is the true hero of our health."
Summary
- Liver is the largest internal organ with 500 functions, essential for longevity, immune system, detoxification, and nutrient management. - Fatty liver disease (MAFLD) affects 38% globally, rising sharply, linked to cardiovascular disease, diabetes, and cognitive decline. - 70% of liver disease isn't due to alcohol but processed foods, preservatives, toxins; fatty liver is a "silent killer" showing few early symptoms. - Liver regenerates uniquely, but damage leads to scarring, fibrosis, cirrhosis; stem cell technology shows promise to reverse cirrhosis. - Diagnosis improved by Fibroscan technology; fatty liver disease is reversible with lifestyle changes and phytomedicine like Deliverance.
Article
The overlooked hero: How your liver could be the key to longevity, according to biohacking expert
At the cutting edge of health optimisation, attention turns to the organ performing 500 vital functions yet receiving minimal recognition
'The silent killer' takes centre stage at European biohacking summit
The liver – an organ roughly the size of a Chihuahua – emerged as the unexpected star at this year's HOLOLIFE Summit in Tallinn, Estonia, where health optimisation experts gathered to discuss the latest advances in longevity science.
In a compelling presentation titled "The Biohacker's Guide to a High-Performing Liver," Siggi Clavien, founder and CEO of The Liver Clinic and de-liver-ance, revealed why this overlooked organ may be the most critical factor in our quest for extended healthspan.
"The liver is the master organ and the general that commands all your other troops and organs, central in regulating vital functions across the body," Clavien told the audience at the three-day summit, which ran from 13-15 June 2025.
A ticking time bomb of disease
While most major diseases have shown downward trends over the past five decades, liver disease has bucked the pattern with alarming results. According to Clavien, liver disease rates have increased by 400% since the 1970s and are accelerating at an unprecedented pace.
"Liver disease is the silent killer because it has no nerves, so you don't feel it until it's too late," he warned, noting that the condition is projected to become the number one killer of preventable disease globally by 2030-2035.
Perhaps most startling was the revelation that alcohol – long considered the primary culprit in liver damage – accounts for only a minority of cases. "Seventy percent of liver disease on this planet is not because of alcohol, but primarily caused by processed foods and toxins," Clavien explained.
The epidemic hiding in plain sight
The statistics presented painted a sobering picture. Metabolic Associated Fatty Liver Disease (MAFLD) – previously known as non-alcoholic fatty liver disease – now affects 38% of people in Western countries. Among adults aged 40-65, this figure rises to a staggering 63%.
In corporate workplace screenings, the numbers were even more alarming. "At JP Morgan, 70% of traders had fatty liver disease," Clavien said, highlighting how the condition has silently infiltrated even seemingly healthy populations.
The global scale of the problem is equally concerning, with 1.5 billion people currently affected by fatty liver disease – a number projected to increase by 350 million in the next seven years.
Beyond the liver itself
Clavien's presentation emphasised that liver health extends far beyond the organ itself, potentially affecting nearly every system in the body.
"We hypothesize – and we will prove – that more people will die of cardiovascular disease because of fatty liver than will die of liver cancer," he said, referencing ongoing research with University of California, Irvine and Mayo Clinic.
The liver's influence extends to cognitive function as well. "A key early symptom is brain fog," Clavien noted, explaining how fatty liver disease impairs neurological function, potentially contributing to conditions like Alzheimer's disease.
Detection challenges and breakthroughs
One of the most significant obstacles to addressing the liver crisis has been diagnostic limitations. Traditional blood tests – the standard method globally – often fail to detect problems until significant damage has occurred.
"Eighty to ninety percent of fatty liver disease cases do NOT show up on a blood test," Clavien revealed.
The presentation highlighted more advanced technologies, particularly the Fibroscan – a device that uses sound waves and vibration to assess liver health with remarkable precision. Originally developed to test cheese ripeness, this technology has become the gold standard for non-invasive liver assessment.
Rays of hope
Despite the alarming statistics, Clavien's message was ultimately one of optimism. "Fatty liver disease is reversible, and through healthy lifestyle and advanced phytomedicine, we can save the hero and reclaim our health," he said.
The entrepreneur showcased de-liver-ance, a plant-based phytomedicine developed over 18 years of research and clinical trials. According to Clavien, the formula optimises liver function, enhances mental clarity, supports immune function, and aids toxin elimination.
Perhaps most exciting was the revelation about potential new frontiers in treatment. "We now believe that cirrhosis may be reversible," Clavien said, describing collaborative work with stem cell experts exploring technologies to potentially reverse even advanced liver damage – something previously thought impossible.
The path forward
For summit attendees seeking practical advice, Clavien emphasised the importance of movement, exercise, and avoiding processed foods.
"Keep the liver soft, squishy, and moving," he advised, explaining that the organ can expand by up to 40% after a large meal before returning to its normal size.
As the HOLOLIFE Summit concluded its first day, Clavien's presentation left attendees with a renewed appreciation for what he called "the hero organ" and a clear message that optimising liver health may be the overlooked key to achieving the longevity goals that brought them to Tallinn in the first place.
"The liver is the most important organ for longevity, the most important organ for your immune system, and the most important organ for detoxification," Clavien concluded. "It's time we gave it the attention it deserves."
Part of HOLOLIFE Summit 2025 Tallinn