Regenerative Aesthetics & Biological Aging
Dr. Mari Laasma — Aesthetic Medicine Specialist, Founder @ Dr. Mari Laasma Laser & Beauty Clinic
Mari Laasma is a pediatric surgeon and aesthetic medicine specialist, known for founding the Dr. Mari Laasma Laser and Beauty Clinic. With over 20 years of clinical experience, she expertly integrates cutting-edge technologies like energy-based devices and regenerative medicine into her practice. Mari’s personalized, holistic approach involves detailed diagnostics, including blood tests, hormone analysis, and genetic testing, to tailor treatments to each patient. Her philosophy on anti-aging emphasizes vitality, confidence, and health, aiming for natural, subtle results.
Aging primarily results from collagen, elastin, bone, muscle, and fat loss, accelerated by UV exposure, oxidative stress, sugar, pollution, and inflammation. Regenerative aesthetic medicine harnesses autologous treatments like platelet-rich plasma and stromal vascular fraction, alongside non-autologous exosomes and polynucleotides to stimulate collagen and cellular repair. Advanced technology including AI, lasers, radiofrequency, cryotherapy, and photobiostimulation targets skin rejuvenation at cellular and mitochondrial levels. Personalized strategies consider biological age, hormonal balance, and lifestyle factors including diet, resistance training, cold exposure, sleep, and skincare for healthy, youthful skin.
"The natural healing force within each of us is the greatest force in getting well."
Summary
- No magic pill for aging; resistance training and personalized treatments are key. - Beauty linked to facial symmetry, collagen, bone, muscle, and skin health reflecting inner well-being. - Aging mostly influenced (80%) by epigenetics, amenable to lifestyle and regenerative treatments. - Regenerative aesthetic medicine uses body's own cells, PRP, fat grafts, and energy-based devices to boost collagen and healing. - Biohacking routines include cold exposure, sauna, sleep, resistance training, supplements, skincare, and laser therapies.
Article
Regenerative medicine revolutionises anti-aging approach, expert reveals at HOLOLIFE Summit
Pediatric surgeon and aesthetic specialist highlights how biology, not fillers, holds the key to lasting youth
A paradigm shift is occurring in aesthetic medicine, moving away from simply "filling lines" toward harnessing the body's own regenerative capabilities, according to renowned Estonian physician Dr. Mari Laasma. Speaking at the HOLOLIFE Summit 2025 Europe in Tallinn on Friday, Dr. Laasma presented compelling evidence that true anti-aging success lies in understanding and manipulating biological processes rather than seeking quick cosmetic fixes.
"Eighty percent of aging is influenced by epigenetics, which means most of it is within our control to improve," Dr. Laasma told the audience of health professionals and biohacking enthusiasts gathered at the three-day event.
The science of beauty goes beyond skin deep
Dr. Laasma, founder of the Dr. Mari Laasma Laser and Beauty Clinic, explained that the visible signs of aging stem primarily from the loss of collagen, elastin, bone, muscle and fat – processes accelerated by environmental factors such as UV exposure, oxidative stress, sugar consumption, pollution and inflammation.
While facial symmetry and golden ratio proportions remain mathematically relevant to beauty standards, Dr. Laasma emphasised that skin health acts as the ultimate reflection of overall wellbeing. "Healthy, glowing skin is the only mirror that truly reveals what's happening inside our bodies," she noted.
The presentation revealed how modern aesthetic medicine has evolved to address aging across all five facial layers – skin, subcutaneous fat, muscles, ligaments and bone structure – rather than merely targeting surface-level concerns.
From autologous to technological: the regenerative toolbox
The most promising developments in the field involve harnessing the body's innate healing abilities. "In regenerative medicine, we use the body's own capabilities to heal and rejuvenate, stimulating collagen and elastin production," Dr. Laasma explained.
Autologous treatments – those using a patient's own biological materials – were highlighted as particularly effective. These include platelet-rich plasma (PRP), stromal vascular fraction from fat tissue, and various forms of processed fat grafts. Non-autologous options such as exosomes and polynucleotides were also discussed, though Dr. Laasma noted that European regulations limit some applications.
The presentation also covered advanced technologies transforming the field, including:
- Photobiostimulation using red light therapy to enhance mitochondrial function - Laser treatments for skin tightening and collagen stimulation - Radiofrequency and ultrasound devices for non-surgical lifting - AI-assisted diagnostics and treatment planning
"Lasers and energy-based devices lift, tighten, and rejuvenate the skin by promoting cellular repair and reducing biological age," Dr. Laasma said, emphasising that these technologies have demonstrated measurable epigenetic improvements.
The lifestyle foundation of youthful appearance
Perhaps most surprisingly for an aesthetic medicine expert, Dr. Laasma placed significant emphasis on lifestyle factors that support skin health and longevity.
"Resistance training might be the best recommendation we have to stay strong and healthy as we age," she stated, highlighting its particular importance for women experiencing perimenopause and menopause.
Other key components of her recommended biohacking routine included cold water immersion, sauna use, quality sleep, strategic supplementation, and comprehensive skincare with UV protection. She dismissed the notion of a "magic pill" for aging, instead advocating for personalised approaches based on detailed diagnostics including biological age testing, hormone analysis, and genetic screening.
A new philosophy of aging
The presentation reflected a broader cultural shift in attitudes toward aging. "Recently, seventy-five percent of consumers focused more on 'looking well-aging' instead of anti-aging," Dr. Laasma noted, suggesting that complete age denial is being replaced by a desire to maintain health and vitality throughout the lifespan.
This perspective aligns with the summit's overall focus on holistic approaches to health and longevity, with speakers addressing everything from gut health to brain optimisation across the three-day event.
As the HOLOLIFE Summit continues through Sunday in Tallinn, attendees will explore additional cutting-edge topics at the intersection of health technology and human potential. Dr. Laasma's presentation, however, has already established a central theme: the future of anti-aging lies not in concealing the signs of time, but in fundamentally changing how our biology responds to it.
Part of HOLOLIFE Summit 2025 Tallinn