Nutritional Ketosis - The Mountain of Evidence
Dorian Greenow — Founder @ Keto-Mojo, Co-Founder & President @ The Ketogenic Foundation
Dorian Greenow is a catalyst in the ketogenic health movement. After losing 22 kilos and reversing metabolic conditions through a ketogenic lifestyle, he founded Keto-Mojo in 2017 to provide affordable, accurate blood glucose and ketone meters. His innovations include the GKI and GK+ meters and the MyMojoHealth platform, a tool for real-time health monitoring. Dorian participates in over 80 clinical trials and speaks at global conferences to highlight the science of ketosis. He and his wife Gemma also established The Ketogenic Foundation to advance ketogenic education and research.
Nutritional ketosis, an evolutionary default state, offers metabolic flexibility by providing a mix of glucose and ketones as fuel, stabilizing blood sugar and reducing insulin. It improves brain health, inflammation, and longevity through epigenetic regulation, enhanced ATP function, and increased BDNF. Clinical trials demonstrate significant reversals of type 2 diabetes, epilepsy, and bipolar disorder, with metabolic psychiatry emerging. Contrasting with hyperinsulinemic glucose metabolism from high-carb diets causing chronic disease, ketogenic interventions restore metabolic health and empower patients for preventive and therapeutic benefits.
"Ketosis is the evolutionary default nutritional status for humanity and without doubt the optimal biohack—giving your body metabolic flexibility, improved energy, brain function, reduced inflammation, and longevity. Optimization is better than cure."
Summary
- Nutritional ketosis offers metabolic flexibility with ketones and glucose as fuel, improving brain function and energy stability. - Ketones act as signaling molecules, reducing inflammation and aiding conditions like PCOS, bipolar disorder, and migraines. - Excess carbohydrate intake causes hyperinsulinemia, driving diabetes and chronic diseases; ketogenic diet reverses many effects. - Over 570 studies support keto benefits for diabetes, obesity, neurological disorders, and liver disease, with clinical success in reversal. - Ketosis is proposed as humanity’s evolutionary default, optimizing health, longevity, cognitive function, and reducing inflammation and oxidative stress.
Article
Mounting evidence shows nutritional ketosis could revolutionise metabolic health, expert reveals
Keto pioneer presents comprehensive research at international health summit
A compelling case for nutritional ketosis as a powerful intervention for metabolic health and disease reversal was presented at the HOLOLIFE Summit 2025 Europe in Tallinn this weekend. Dorian Greenow, founder of Keto-Mojo and a prominent figure in ketogenic health research, delivered a comprehensive overview of the scientific evidence supporting ketosis in his talk titled "Nutritional Ketosis - The Mountain of Evidence."
An evolutionary approach to metabolism
Greenow began by framing nutritional ketosis not as a fad diet but as humanity's evolutionary default metabolic state. "For most of human history, our bodies regularly entered ketosis between meals and during seasonal food scarcity," Greenow explained to the audience of health professionals and researchers. "Our modern, carbohydrate-rich diet has disrupted this natural metabolic flexibility."
The presentation detailed how ketosis provides the body with dual fuel sources – glucose and ketones – leading to more stable blood sugar levels and reduced insulin requirements. This metabolic state, according to the growing body of research Greenow presented, creates cascading benefits throughout the body's systems.
Clinical evidence for disease reversal
Perhaps most striking were the clinical outcomes Greenow shared from recent trials. Multiple studies have now demonstrated significant reversal of type 2 diabetes through ketogenic interventions, with patients reducing or eliminating medication while achieving improved biomarkers.
"What we're seeing isn't just management of these conditions – it's genuine reversal," Greenow said. He highlighted research showing how nutritional ketosis influences inflammation pathways, brain health, and longevity markers through epigenetic regulation and enhanced mitochondrial function.
The audience appeared particularly interested in emerging research on "metabolic psychiatry," where ketogenic approaches have shown promise in conditions including epilepsy and bipolar disorder. Greenow referenced several controlled trials showing improvement in neurological symptoms through targeted metabolic interventions.
Challenging conventional dietary wisdom
Greenow didn't shy away from addressing how these findings contrast with decades of conventional dietary advice. He presented data linking hyperinsulinemia from high-carbohydrate diets to various chronic diseases that plague modern society.
"The standard nutritional advice to consume 55-60% of calories from carbohydrates simply doesn't align with our evolutionary biology or the clinical evidence," he argued. "We've been running a population-wide experiment with high-carb diets for decades, and the results – rising rates of obesity, diabetes, and metabolic syndrome – speak for themselves."
Empowering patients through metabolic health
Looking to the future, Greenow emphasized the potential for ketogenic approaches to shift healthcare toward prevention rather than management of chronic disease. His own company's development of affordable ketone monitoring technology aims to democratize access to these health insights.
"When patients can see in real-time how dietary choices affect their metabolism, it transforms their relationship with food and health," Greenow noted. He shared case studies of individuals who reversed metabolic conditions through monitored ketogenic interventions.
The three-day HOLOLIFE Summit, running from June 13th to 15th, has brought together leading researchers and clinicians exploring innovative approaches to health optimization. Greenow's presentation, with its focus on the scientific foundation of ketosis rather than sensationalist claims, provided what many attendees described as a highlight of the conference.
As healthcare systems worldwide struggle with rising chronic disease burdens, Greenow's evidence-based approach to nutritional ketosis offers a potentially transformative path forward – one that returns human metabolism to its evolutionary roots while leveraging modern science to optimize health outcomes.
Part of HOLOLIFE Summit 2025 Tallinn